Aminoglycoside nephrotoxicity kidney international. Gentamicin gnt is an aminoglycoside antibiotic used for treatment of. Research article renal protective effect of hesperidin on gentamicin induced acute nephrotoxicity in male wistar albino rats ramaswamy anandan, perumal subramanian department of biochemistry and biotechnology, faculty of science, annamalai university, annamalainagar, tamil nadu, india. In recent years gentamicin nephrotoxicity is significantly reduced by shifting to once daily dosage as well as by eliminating known risk factors. Abstract objective to evaluate nephroprotective potential of solanum xanthocarpum s. Nephrotoxicity was induced in rats by intraperitoneal injection i. Aminoglycosides have long been one of the commonest causes of drug induced nephrotoxicity. Lerner sa, schmitt ba, seligsohn r, matz g comparative study of ototoxicity and nephrotoxicity in patients randomly assigned to treatment with amikacin or gentamicin. Sep 23, 2019 pioglitazone attenuates kidney injury in an experimental model of gentamicininduced nephrotoxicity in rats. These results indicate that gentamicin induces inos expression through activation of nf. The kidneys are susceptible to oxidant induced injury due their high reliance on mitochondria and atp to facilitate the transport function of the nephron. Due to high relative blood flow the kidney is prone to druginduced damage. The aminoglycoside antibiotic gentamicin can cause both ototoxicity and nephrotoxicity, the severity of which varies with circadian time of daily treatment.
Structural latency of lysosomal nacetyl3glucosaminidasefollowing gentamicin treatment mean of four independent experiments sem. Effect of normobaric hyperoxia on gentamicininduced. Citrus medica, nephrotoxicity, antioxidant activity, oxidative stress, gentamicin 1. The plant extract of rhazya stricta has been noted to dosedependently increase the superoxide dismutase activity and the reducedform of glutathione and subsequently decrease lipid peroxides in the renal cortex of gentamicin administered rats. Gentamicin induced acute renal damage and its evaluation using. This article is from iranian journal of basic medical sciences, volume 16.
Mar 31, 2015 molecular mechanism of drug induced nephrotoxicity 1. Gentamicin gm is a widely used antibiotic against serious and lifethreatening infections, but its usefulness is limited by the development of nephrotoxicity. Gentamicininduced nephrotoxicity kidney international. However, there are still controversies and speculation about the precise mechanism of action. In the kidney, gnt induced increase in the level of no. Protective effect of apocynin against gentamicininduced. Effect of normobaric hyperoxia on gentamicin induced nephrotoxicity in rats. In patients receiving gentamicin for 3 to 5 days, nephrotoxicity occurs in 10% to 25% of the cases.
As such, the mechanisms of oxidant induced injury have been a focus of nephrotoxicity for decades. The cessation of the treatment allows a recovery to control values within approximately 8 days. Pioglitazone attenuates kidney injury in an experimental. Gentamicin is an antibiotic, the clinical use being partially limited due to nephrotoxicity. Gentamicin injection is a sterile, nonpyrogenic aqueous solution for parenteral administration. Methods twentyfour wistar rats were divided into four groups n6. Experimental gentamicin nephrotoxicity and agents that modify it.
Antibiotics are a widespread class of drugs and the principal cause of drugassociated nephropathy. Our results suggested that hdn acts as a potent scavenger of free radicals in the kidney to prevent the toxic effects of gen both at the biochemical and. Dec 27, 2019 aminoglycosides preferentially affect the proximal tubular cells. Gentamicin gnt is an aminoglycoside antibiotic used for treatment.
Symposium on drug effects on the kidney gentamicininduced nephrotoxicity. Diagnosis and treatment aminoglycoside nephrotoxicity typically is associated with nonoliguric acute renal failure, that is, azotemia in the presence. These agents are freely filtered by the glomeruli and quickly taken up by the proximal tubular epithelial cells, where they are incorporated into lysosomes after first interacting with phospholipids on the brush border membranes. Nephrotoxicity definition of nephrotoxicity by medical.
Pinocembrin attenuates gentamicininduced nephrotoxicity in. Gentamicin induced nephrotoxicity 585 gentamicin for 8 days, mgkg fig. A number of crude herbal extracts have been reported to ameliorate gentamicin induced nephrotoxicity. However, due to its side effects, there are some limitations in the use of gentamicin and streptomycin. Gentamicin gnt is an aminoglycoside antibiotic used for treatment of serious infections, and the nephrotoxic adverse effect is one of the main therapeutic limitations.
Effects of cosupplementation of vitamins e and c on. Gentamicin gm induced nephrotoxicity may be sex hormones related. Gentamicininduced nephrotoxicity in rats ameliorated and healing effects of resveratrol. Dailymed gentamicin gentamicin sulfate injection, solution. Gentamicininduced acute renal failure model creative biolabs. It is possible to prevent gentamicin induced nephrotoxicity using selective nf. Protective effect of apocynin against gentamicininduced nephrotoxicity in rats. This study aimed to investigate the possible protective effect of apocynin apo on nephrotoxicity induced by gnt in rats. International institute of cellular and molecular pathology. In this study we investigated the role of free radicals in gentamicin. The effects of sex hormones on gm induced nephrotoxicity in gonadectomized rats were investigated. Does propylthiouracil increase the gentamicininduced. A recent prospective study of hospitalacquired acute renal failure in 2116 patients revealed that 11% of the cases probably were related to aminoglycoside use 2.
Protective effect of crocin on gentamicininduced nephrotoxicity in rats. Approximately 5 % of the administered dose accumulates within these cells after glomerular filtration 2. Aminoglycoside type antibiotic gentamicin is one of the leading cause of druginduced nephrotoxicity. Although a clear recognition of the patient and treatmentrelated risk factors, combined with the onceaday schedule and effective monitoring procedures, have definitely improved the situation over what prevailed in the early 1980s, we are still short of having brought the safety of. Nov 21, 2016 gentamicin sulfate, a watersoluble antibiotic of the aminoglycoside group, is derived by the growth of micromonospora purpurea, an actinomycete. Gentamicin is a very effective antibiotic in treating gramnegative bacterial infection in both humans and animals. Aminoglycosideinduced nephrotoxicity is characterised by selectivetargetingoftheproximaltubuleepithelialcellswith in the renal cortex. B, pyrolidium dithiocarbamate, sulfasalazine, gentamicin, nephrotoxicity, inos objective. Plasma creatinine and ureanitrogen concentrations, oxidative stress and histopathological changes of kidney tissues were monitored. Finally, gentamicin nephrotoxicity is potentiated by magnesium depletion 27. Melatonin synergistically enhances protective effect of atorvastatin against gentamicininduced nephrotoxicity in rat kidney. Nephrotoxicity definition of nephrotoxicity by the free. Gentamicin induced nephrotoxicity is a models of acute.
Comparative study on gentamicin and streptomycin induced. Antioxidant vitamins modified gentamicin induced nephrotoxicity in both genders, with some difference in response to vitamins e and c between the genders, that was higher in female. The aminoglycoside antibiotic gentamicin gm is still widely used against. Pdf gentamicin induced nephrotoxicity in albino mice. Mar 24, 2017 gentamicin induced nephrotoxicity has been extensively studied in the past and has become one of the established models of drug induced nephrotoxicity.
Pdf how to prevent, recognize, and treat druginduced. However, it is not yet resolved if such drug induced adverse effects are independent or dependent. The present study was designed to determine the protective effect of salicylic acid sa in gentamicin induced nephrotoxicity in rats. Gentamicin induced nephrotoxicity in sprague dawley rats is. Aminoglycosides are among the oldest antibiotics available to treat serious infections caused by primarily, gramnegative bacteria. Aminoglycosides have long been one of the common causes of drug inducednephrotoxicity. Concomitant gentamicininduced nephrotoxicity and bilateral. Effects of pentoxifylline on gentamicininduced nephrotoxicity. One of the complications of gentamicin and streptomycin is nephrotoxicity. Qadir and others published gentamicin induced nephrotoxicity in. Concomitant gentamicin induced nephrotoxicity and bilateral ototoxicity aa akinbodewa 1, o okunola 2 1 department of medicine, kidney care centre, university of medical sciences, ondo, ondo state, nigeria 2 department of renal unit, obafemi awolowo university teaching hospital, ile ife, osun state, nigeria. The aim of this study was to evaluate the effect of subacute.
Gentamicininduced ototoxicity and nephrotoxicity vary. Protection against gentamicin induced early renal alterations phospholipidosis and increased dna synthesis by coadministration of polylaspartic acid. Gentamicin and streptomycin are the most common antibiotics in group of aminoglycosides. Gentamicin is rapidly excreted predominantly by glomerular filtration and reabsorption by the proximal tubules results in accumulation within the renal cortex. Gentamicin induced nephrotoxicity was indicated by the reduced renal function and renal oat3 function and expression. Nephrotoxicity induced by gentamicin is a complex situation characterized by an increase in blood urea nitrogen bun and serum creatinine concentration, and tubular necrosis. Agents ameliorating or augmenting experimental gentamicin nephrotoxicity.
We performed a retrospective observational study to examine this and the predictive value of rifle stage on patient outcome in this setting. Salicylic acid attenuates gentamicininduced nephrotoxicity. Pdf in this study, we aimed to investigate the possible protective effect of resveratrol on. Research article protective effects of cilastatin against vancomycininduced nephrotoxicity blanca humanes,1 juan carlos jado,1 sonia camano,1 virginia lopezparra,1 ana maria torres,1 luis antonio alvarezsala,2,3 emilia cercenado,2,4 alberto tejedor,1,2 and alberto lazaro1 1. This is especially true of the proximal tubule cells. Renal protective effect of hesperidin on gentamicininduced acute. Melatonin synergistically enhances protective effect of. The most commonly utilized parenteral agents in this class include gentamicin, tobramycin and amikacin. Pioglitazone attenuates kidney injury in an experimental model of gentamicininduced nephrotoxicity in rats.
Nephroprotective activity of solanum xanthocarpum fruit. Mechanisms of aminoglycosideinduced nephrotoxicity. Pdf gentamicininduced nephrotoxicity in rats ameliorated and. Saeed mehrzadi, a seyed kamran kamrava, b banafshe dormanesh, c manijeh motevalian, a azam hosseinzadeh, a seyed mohammad taghi hosseini tabatabaei, d habib ghaznavi e.
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